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CFDRC News!

Missile Defense Agency TechUpdate "Modeling the Real World"

CFDRC Wins a $5M Hydrogen Fuel Cell project from DoE

CFDRC Files Patent for "Advanced Multipurpose Pseudospark Switch"

CFDRC is awarded Patent for "Electrothermally Induced Flow for Mixing and Cleaning in Microsystems"

CFDRC Files Patent Application for "Synthesis of Carbon Nanotubes by Selectively Heating Catalyst"

CFDRC Files Patent Application for "Integrated Microfluidic System Design "

Biochip Applications

Our engineers have designed and analyzed (point to chip design examples) a vast range of biomicrosystems for genomic and proteomic analysis, drug discovery and high-throughput screening applications and bio-diagnostics/theranostics.

Comparison of CFD-ACE+ simulation and experiments of sample multiplexing (experimental images courtesy of Prof. Chong Ahn, U. Cincinnati)

Example application platforms include:

Lab-On-A-Chip
Microanalytical Systems
Microarray Platforms
DNA Chips
Protein Chips
Biosensors
Cell Based Devices

Multiple, complex, interacting physicochemical phenomena occurring within the biotech/microfluidic applications are analyzed and optimized using CFD-ACE+ software. A non-exhaustive list of capabilities/features is described below.

Microfluidics	Biochemistry	Electrokinetics/Chemistry
Hydrophobic / Hydrophilic Filling and Dispensing Pressure Driven Flow Taylor-Aris Dispersion Sample Mixing Particle/Cell Transport Fluid-Structure Interaction Heat Transfer (PCR Cycling)	Mass Transport or Kinetics-Limited Binding Antigen-Antibody, Ligand-Receptor Binding Multi-Protein, Multi-Receptor, Competitive Binding DNA Hybridization Surface or Volume-Immobilized Enzyme Catalysis (Michaelis-Menten) Microsphere-based Detection (Immunoassays)	Electroosmosis/Electrophoresis Ionization Involving Acid/Base Reactions, Ampholyte Chemistry Modes of Focusing / Separation - Isoelectric Focusing, Isotachophoresis, pH Gradient Electrophoresis, CE-ITP, etc. Field Amplified Sample Stacking Electrochemical Sensing Conventional & Traveling Wave Dielectrophoresis Sample Dispersion Under EOF Electromagnetics AC/DC Electric Fields Joule Heating Electrokinetic Injection