| In DPIs, the drug is contained in a powder form. Upon actuation, a measured
dose is entrained in the air stream and subsequently inhaled. CFDRC engineers
have developed the technology to analyze and optimize powder entrainment,
powder dispersion, and powder delivery.
In the example shown, we compare two alternatives for the location of
a compressed air inlet designed to entrain powder from a blister. A radially
entering jet is seen to entrain the blister faster, but leaves a residue.
Understanding design tradeoffs similar to this is critical to the design
of a good dry powder inhaler.
Powder Entrainment in a DPI - Simulation Set-Up
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Powder Entrainment in a DPI
Simulation results
Co-Axial Air Jet (Slow, leaves residue)
Crossflow Air Jet (faster, no residue)
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