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Objective
Our objective is to provide solutions to critical problems in military and civilian medicine through the strategic development of quantitative, predictive bioinformatics and systems biology tools for the analysis of cellular biochemical systems.
Tools and Solutions
The Systems Biology and Bioinformatics group has a solid track record of providing computational solutions for life sciences applications to address the need for both basic research and application development using existing and emerging systems biology and bioinformatics methodologies.
Systems biology solutions include the development of customized computational methods to enable the construction of intracellular pathway models, and associated quantitative, dynamic, predictive algorithms to analyze the resultant pathway models for use in biomarker discovery, assay design, and therapeutic target identification. Bioinformatics solutions include development of customized database solutions for storage and management of large complex datasets, and advanced analysis tools for the integrated interpretation of the large heterogeneous (genomic, proteomic, metabolomic) datasets in proper biological pathway context. |
We offer a diverse array of systems biology and bioinformatics solutions by providing customized consulting, research and development through close collaboration.
Current Application Areas
Our current application areas include malaria and toxicology, encompassing various scientific disciplines including genomics, proteomics and metabolomics, pathology, toxicology and pharmacology.
Malaria
The systems biology and bioinformatics group at CFDRC is aiding in the fight against malaria on three fronts: sustainable development of lead antimalarial compounds using natural product extracts, understanding host-pathogen interactions and immunomodulatory effects of hemozoin that lead to successful parasitism, and development of genetic tests to identify individuals that are susceptible to antimalarial neurotoxicity associated with mefloquine.
Toxicology and Toxin Discrimination
Development of predictive, dynamic intracellular pathway models of cellular response to toxins with the goal of developing pre- and post-exposure therapeutics for civilian and military applications is a focus are of the systems biology and bioinformatics group at CFDRC. Our efforts have focused primarily on preventing and treating nerve agent exposure, noise induced hearing loss, and toxin discrimination using either neuron action potentials or dynamic external metabolic measurements.
Publications
The Systems Biology and Bioinformatics group is an extremely diverse group, with a publication record that covers a wide array of applications and fundamental developments.
If you are a potential collaborator or are interested in learning about our services, please contact us.
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