Integrated systems biology (bottom up) and systems physiology (top down) modeling, referred as CMB, will soon become one of the most dynamic areas of scientific and commercial biomedical and pharmacological discovery.

CFDRC is developing a new generation of multiscale modeling tools integrating whole body physiology (circulation, respiration, metabolism, autoregulation) with organ/tissue physiology coupled to systems biology (intra/intercellular gene and protein networks, signaling and metabolic pathways). The core simulation engine, CoBi, and graphical GUI model generator JCoBi, provide the framework for the Leonardo – a virtual “living” human (mouse, pig, etc.).

Our multi time/space scale modeling approach in CoBi enables seamless coupling between compartmental and spatially (1D-3D) resolved parts of the body. Depending on the application we may use compartmental model of the whole body physiology coupled to a 3D model of an artery section (hemodynamics, vessel/tissue mechanics), to a distributed set of tissue embedded points of biological cell models. Our multiscale modeling tools have been used to simulate range of applications in pathophysiology (trauma, hemorrhage, diabetes, brain injury), to drug delivery (drug coated stents, inhalers), pharmacology (antibiotics, steroids, contrast agents, drug screening), and toxicology (genetic screening, neurotoxicology).

See example disciplines below:

• Systems Physiology and Pathophysiology
  - Hemodynamics, respiration, autoregulation, metabolism, immunology
  - Diabetes, aneurysm, atherosclerosis, tumor angiogenesis
  - Model based detection and treatment (heart valves, stents, NIRS, inhalation)

• Pharmacology
  - New generation tools: whole body PBPK, PK, PD, Toxicity, ADME,
  - Treatments: antimalarial, antibiotics, vascular, chemotherapeutics

• Biomechanics and Injury
  - traumatic lung and brain injury, hemorrhage

• Leonardo Family

Please contact us for more information about computational medicine and biology research activities.