The Biochemistry Module in CFD-ACE+ is capable of simulating different types of biomolecular bulk flow and surface reactions (analyte-receptor interactions, enzyme catalysis). Following are some of the features of the Biochemistry Module:

• Binding Kinetics
• Surface Reaction Models
• Bulk Reaction Models
• Enzyme Catalysis
• Microsphere (Beads) Based Immunoassay

Analyte transport occurs in the flow domain by convection (or advection), forced drift (gravity, electrophoresis) and diffusion. It is also influenced by the rate of surface reaction that locally alters the analyte concentration adjacent to reacting surfaces and sets up concentration gradients. Mass transport influences surface binding as it determines the residence time of the analyte near the binding sites (or receptor sites) along the reacting surfaces. Thus analyte mass transport and the surface binding processes have a complex interdependence on each other, and depend on flow geometry, analyte diffusivity, surface reaction rate constants, etc. The Biochemistry Module accounts for these factors while simulating analyte transport and surface reaction phenomena.

The Biochemistry Module has been validated and successfully used for many Biomedical and Life Sciences Applications.